2019

Yokokawa K, Iwahara N, Hisahara S, Emoto MC, Saito T, Suzuki H, Manabe T, Matsumura A, Matsushita T, Suzuki S, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S. Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. J Alzheimers Dis. 2019: 72; 867-884.

 

Saito T, Hisahara S, Iwahara N, Emoto MC, Yokokawa K, Suzuki H, Manabe T, Matsumura A, Suzuki S, Matsushita T, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S. Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease. Free Radic Biol Med. 2019;145:20-32.

 

Fujii HG, Emoto MC, Sato-Akaba H. Brain Redox Imaging Using In Vivo Electron Paramagnetic Resonance Imaging and Nitroxide Imaging Probes. Magnetochemistry. 2019: 5; 11-22.

 

Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S. Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy. J Alzheimers Dis. 2019: 67; 1079-1087.

 

Emoto CM, Sato-Akaba H, Matsuoka Y, Yamada KI, Fujii GH, Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model. Neurosci Lett. 2019: 690; 6-10.

 

2018

Emoto CM, K Segawa K, Maeda K, Fujii GH, Sato S. Synthesis and evaluation as a blood-brain barrier-permeable probe of 7-N-(PROXYL-3-yl-methyl)theophylline. Chem Pharm Bull. 2018: 66 887-891.

 

2017

Sato-Akaba H, Emoto CM, Hirata H, Fujii GH. Design and testing of a 750 MHz CW-EPR digital console for small animal imaging. J Magn Reson. 2017: 284; 48-58.

 

Emoto CM, Matsuoka Y, Yamada KI, Sato-Akaba H, Fujii GH, Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging. Biochem Biophy Res Commun. 2017: 485; 802-806.

 

2016

Sasaki K, Ito T, Fujii GH, Sato S. Synthesis and reduction kinetics of five ibuprofen-nitroxides for ascorbic acid and methyl radicals. Chem Pharm Bull, 2016: 64; 1509-1513.

 

Wang X, Emoto M, Sugimoto A, Miyake Y, Itto K, Xu S, Hirata H, Fujii H, Arimoto H.  Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging. Bioorganic & Medicinal Chemistry Letters  2016: 26; 4947-4949.

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Emoto CM, Sato S, Fujii GH.  Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI. Magn Reson Chem. 2016: 54; 705-711.

 

2015

Emoto CM, Yamato M, Sato-Akaba H, Yamada K, Fujii GH. Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe. Neuroscience Letters 2015: 608; 40-44.

 

Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S. Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging. Free Rad Biol Med. 2015: 85; 165-173.

 

Emoto CM, Yamato M, Sato-Akaba H, Yamada K, Fujii GH. Brain Imaging in Methamphetamine-Treated Mice using a Nitroxide Contrast Agent for EPR Imaging of the Redox Status and a Gadolinium Contrast Agent for MRI Observation of Blood-Brain Barrier Function. Free Rad Res 2015: 49; 1038-1047.

 

2014

Emoto CM, Sato-Akaba H, Hirata H, Fujii GH. Dynamic changes in the distribution and time-course of blood-brain barrier-permeable nitroxides in the mouse head with EPR imaging: Visualization of blood flow in a mouse model of ischemia. Free Rad Biol Med. 2014: 74; 222-228.

 

Wang X, Emoto M, Sugimoto A, Miyake Y, Itto K, Amasaka M, Xu S, Hirata H, Fujii H, Arimoto H. Synthesis of 15N-labeled 4-oxo-2,2,6,6- tetraethylpiperidine nitroxide for EPR brain imaging. Tetrahedron Letters. 2014: 55; 2146-2149.

 

2013

Enomoto A, Emoto M, Fujii H, Hirata H. Four-channel surface coil array for sequential CW-EPR image acquisition. J Magn Reson. 2013: 234; 21-29.

 

Emoto CM, Yamada K, Yamato M, Fujii GH. Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents. Neuroscience Letters. 2013: 546; 11-15.

 

Fujii　HG, Sato-Akaba H, Emoto MC, Itoh K, Ishihara Y, Hirata H. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging. Magn Reson Imag. 2013: 31; 130-138.

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Miyake Y, Wang X, Amasaka M, Itto K, Xu S, Arimoto H, Fujii H, Hirata H. Simultaneous imaging of an enantiomer pair by electron paramagnetic resonance using isotopic nitrogen labeling. Anal Chem. 2013: 85; 985-90.

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Emoto CM, Yamada K, Yamato M, Fujii GH. Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents. Neuroscience Letters. 2013: 546; 11-15.

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2012

Koda S, Goodwin J, Khramtsov VV, Fujii H, Hirata H. Electron Paramagnetic Resonance-Based pH Mapping Using Spectral-Spatial Imaging of Sequentially Scanned Spectra. Anal Chem. 2012: 84; 3833-3837.

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2011

Ohfuchi M, Goodwin J, Fujii H, Hirata H. Three-dimensional EPR/MRI image co-registration using a MATLAB-based software. Concepts in Magn Reson Part B Magn Reson Engin. 2011: 39B; 180-190.

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Emoto M, Mito F, Yamasaki T, Yamada K, Sato-Akaba H, Hirata H, Fujii H. A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse. Free Radic Res. 2011: 45; 1325-1332.

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Pawlak A, Ito R, Fujii H, Hirata H. Simultaneous molecular imaging based on electron paramagnetic resonance of 14N- and 15N-labelled nitroxyl radicals. Chem Comm. 2011: 47; 3245-3247.

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Fujii H, Sato-Akaba H, Kawanishi K, Hirata H. Mapping of Redox Status in a Brain-Disease Mouse Model by Three-Dimensional EPR Imaging. Mag Reson Med. 2011: 65; 295-303.

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2010

Higaki S, Fujii H, Nagano M, Katagiri S, Takahashi Y. Measurement of pO2 in cultured mouse oocytes using electron paramagnetic resonance oximetry. Biomedical Research 2010: 31; 165-168.

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2009

Sato-Akaba H, Kuwahara Y, Fujii H, Hirata H. Half-life mapping of nitroxyl radicals with three-dimensional electron paramagnetic resonance imaging at an interval of 3.6 seconds. Anal Chem. 2009; 81: 7501-6.

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2008

Sato-Akaba H., Fujii H., Hirata H. Development and testing of a CW-EPR apparatus for imaging of short-lifetime nitroxyl radicals in mouse head. J. Magn. Reson. 193, 191-8 (2008)

 

Sato-Akaba H, Abe H, Fujii H, Hirata H. Slice-selective images of free radicals in mice with modulated field gradient electron paramagnetic resonance (EPR) imaging. Magn. Reson. Med. 59, 885-890 (2008)

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Fujii H, Sakata K, Katsumata Y, Sato R, Kinouchi M, Someya M, Masunaga S, Hareyama M, Swartz HM, Hirata H. Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy. Radiother Oncol. 2008, 86, 354-360.

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2007

Fujii H, Itoh K, Pandian RP, Sakata M, Kuppusamy P, Hirata H. Measuring brain tissue oxygenation under oxidative stress by ESR/MR dual imaging system. Magn Reson Med Sci. 2007;6(2):83-9.

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Kawada Y., Hirata H., Fujii H. Use of multi-coil parallel-gap resonators for co-registration EPR/NMR imaging. J. Mag. Reson. 2007: 184; 29-38.

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2006

Fujii, H. Aoki, M., Haishi, T., Itoh, K., Sakata, M.: Development of an EPR/MR Dual-imaging system as a tool to detect bioradicals. Mag. Reson. Med. Sci. 2006: 5; 17-23

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2004

Fujii, H., Berliner, LJ.: Detection of bioradicals by in vivo L-band electron spin resonance spectrometry (ESR): NMR in Biomedicine, 2004:  17; 311-318

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Hirata, H., Watanabe, H., Itoh, K., Fujii, H.: Decoupling of automatic control systems in a continuous-wave electron paramagnetic resonance spectrometer for biomedical applications: NMR in Biomedicine, 2004: 17;  295-302.

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2002

Fujii, H., Yoshikawa, K., Berliner, L.J.: In Vivo fate of superparamagnetic iron oxides during sepsis Magnetic resonance Imaging, 2002: 20; 271-276.

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1999

Fujii, H., Wan, X., Zhong, J., Berliner, L.J., Yoshikawa, K.: In vivo imaging of spin-trapped nitric oxide in rats with septic shock: MRI spin trapping. Mag. Reson. Med., 1999: 42; 235-239

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1997

Fujii, H., Koscielniak, J., and Berliner, L.J.: Determination and characterization of nitric oxide generation in mice by In vivo L-band EPR spectroscopy.  Mag. Reson. Med., 1997: 38; 565-568

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1987

Berliner, L.J., Fujii, H., Wan, X. and Lukiewicz, S.J.: Feasibility study of imaging a living murine tumor by Electron Paramagnetic Resonance.  Mag. Reson. Med., 1987: 4; 380‑384

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1985

Fujii, H. and Berliner, L.J.: One‑ and two‑dimensional EPR imaging studies on phantoms and plant specimens. Mag. Reson. Med., 1985: 2; 275‑282 

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Berliner, L.J. and Fujii, H.: Magnetic resonance imaging of biological specimens by electron paramagnetic resonance of nitroxide spin labels.  Science, 1985: 227; 517‑519

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